Can we use computers to automate turret operations so they can be used without being manned, or will these turrets require NPCs or players to operate?

Not all the turrets.

Yeah. In 3.3, none of them. It's all manned. In the future, read the Shipyard post, because this talks about the exact same thing. Like Adam was going to say, presumably there isn't enough computer space to do all of them at the same time.

And they won't be as good as getting a regular guy in there.

Obviously, it's almost certainly too early to tell, but do you have early thoughts about how many you'd be able to slave when that time comes?

Not all of them.